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Dystonic reactions, which can occur as a side effect of antipsychotic medications, are characterized by sustained muscle contractions, abnormal postures, and sometimes, involuntary movements. The primary treatment for these reactions is the use of antihistamines, specifically diphenhydramine. Diphenhydramine works by blocking the action of histamine at H1 receptors, which helps alleviate the muscle spasms and other symptoms associated with dystonia.

In emergency settings, diphenhydramine can be administered intravenously or intramuscularly for rapid relief. Other medications, such as anticholinergics (e.g., benztropine), may also be used, but among the options provided, diphenhydramine is recognized for its effectiveness in treating acute dystonic reactions specifically related to antipsychotic medications.

The other medications listed do not primarily target the symptoms of dystonia. Propranolol is a beta-blocker typically used for hypertension and anxiety. Sertraline is an SSRI antidepressant that does not address muscle contractions or acute dystonia. Buspirone is an anxiolytic that does not provide benefits for managing dystonic reactions. Therefore, diphenhydramine is the appropriate